The infamous pirate Jack Sparrow unwittingly sets sail with the Flying Dutchman, the haunted ship with supernatural abilities, when he discovers that he must settle a personal debt to the ghost of his former captain, Davy Jones, who rules the depths of the Oceans.

Thus, the plans of Will and Elizabeth, who, despite being on the verge of marriage, must stand by their friend Jack, are ruined.

Adventures follow with sea monsters, hostile natives, the flashy sorceress Tia, the mysterious appearance of Will's lost father, and the desperate attempt of the pirate hunter Lord Beckett to acquire the infamous Chest of the Dead.